Cook pasta according to directions and drain
In medium sauce pan
Melt 1/2 cup butter, add in flour and whisk until it comes to a simmer.
Slowly add in half and half. Stir until thickens and flour is cooked. Season with salt and pepper.
Add cheddar cheeses 1 cup at a time stirring in between. Add parmesan cheese. Stir until all cheeses are melted and sauce is combined.
Pour sauce over noodles. Stir to coat noodles.
Spray a 9×13 or equivalent baking dish with cooking spray. Spread noodles in dish.
In a small mixing bowl melt 1/4 cup butter. Add seasoned panko and mix to coat. Sprinkle panko mixture over noodles.
Bake at 350 for 15-20 minutes.